(L to R) Variegated doubled-haploid mutant from gamma-irradiated Arabidopsis pollen; Cartoon of chromosome shattering; Micronuclei formation in an Arabidopsis embryo during genome elimination

Welcome to the Haploid Genomics Lab

We are a diverse and dynamic team of researchers working on questions centered around chromosome instability and change using genome elimination as the primary tool for our studies. Genome elimination is a biological phenomenon that can occur in plants and animals during sexual reproduction. An embryo undergoing genome elimination loses an entire parental chromosome set in early development, resulting in haploid offspring that carry only half the expected number of chromosomes. One of the potential outcomes from our work applies to potato breeding and improvement efforts that address challenges in productivity, nutritional needs, environmental stresses and disease resistance for this important food crop.

We are also interested in the mechanistic basis and evolutionary consequences of chromosome instability and change that arise during genome elimination. Using the haploid induction and genome elimination systems in potato and Arabidopsis thaliana, we address pressing questions on genome instability by using genomics, cytogenetics and traditional genetics approaches to ask questions such as:

  • How do cells decide whether to repair or to eliminate unstable chromosomes during genome elimination?

  • What are the underlying mechanisms as well as genotypic and phenotypic consequences of chromothripsis (chromosome shattering) that emerge during genome elimination?

  • What are the outcomes of haploid induction in potato? Are induced potato haploids comparable to induced Arabidopsis haploids?

  • How can we leverage genome elimination in potato to accelerate potato breeding?

Research Opportunities

We are looking for motivated graduate students and postdocs to conduct research in plant genetics and genomics. Currently, we are focused on using cultivated potato (Solanum tuberosum) and Arabidopsis thaliana for studies involving genome elimination, haploid induction and chromosome instability.

If you are interested, please send me an email.