Chromosome dosage analysis by whole genome sequencing
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjg0gxfuw6ir05g4qragGhu0eqmbXFNPPN1tfwZREzL5MrsPNObu9EeEuiLlXjDrruUftkUOQUfkT2M0cKUw4GHLCTvkJjnCVqn6hbVrBqlNTsKLec-bN2q7jqvjb0Pl8r0MraBtCjltDs/s640/trisomy3.jpg) |
Example of chromosome dosage plots. Red diamonds mark the approximate location of the centromere. Sample 1 a diploid individual with normal chromosome dosage while Sample 2 is an individual that has an extra copy of Chr3 (referred to as a primary Chr3 trisomic). |
The entire protocol for chromosome dosage analysis -- from DNA extraction, to library construction, to data analysis is available from
bioprotocol.